Authors: Maryne Dupuy, Anaïs Postec, Mathilde Mullard, Aurélie Chantôme, Philippe Hulin, Régis Brion, Maxime Gueguinou, Laura Regnier, Marie Potier-Cartereau, Bénédicte Brounais-Le Royer, Marc Baud’huin, Steven Georges, François Lamoureux, Benjamin Ory, Françoise Rédini, Christophe Vandier and Franck Verrecchia
Cell Communication and Signaling, 18 December 2024
Seeking new therapeutic targets for Ewing sarcoma, scientists use Axion BioSystems’ AI-powered Omni imager to perform real-time cell proliferation assays.
Research has demonstrated the involvement of potassium channels in many cancers, but this relationship is not fully understood in Ewing sarcoma. Seeking new therapeutic targets for Ewing sarcoma (ES), scientists in this study investigate the transcriptional regulation of KCNA2 and define the involvement of the Kv1.2 channel encoded by KCNA2, using Axion BioSystems’ automated, AI-driven Omni live-cell imaging system to perform real-time cell proliferation assays. Overall, the authors report that their findings show “for the first time the overexpression of KCNA2 in biopsies from ES patients” and suggest KCNA2/Kv1.2 as a potential therapeutic target.
