Maestro ZHT
Axion BioSystems’ Maestro ZHT™ platform measures cell proliferation, death, morphology, attachment, and signaling label-free and in real time. Screen drug and biological candidates in a 384- and 96-well plate formats. Track immune cell-mediated killing, viral infectivity, cancer cell invasiveness, endothelial barrier function, wound healing, and more.
These high-throughput assays are real-time, continuous, and label-free, revealing the full cellular response profile and kinetics using electrical impedance. Get more complete data without the time- and cost-intensive process of repeating multiple endpoint assays.
Key Features
High-throughput live-cell analysis system
Taking care of the assay so you can focus on the science.
>> High-throughput, continuous monitoring of your cells
Up to 384 simultaneous live recordings from your cells. The Maestro ZHT system performs noninvasive electrical measurements from the cultured cell population, circumventing the use of dyes/reporters that can perturb your cell model and confound results. Track activity over hours, days, and weeks from the same population of cells label-free and in real time.
>> Precisely control the cells' environment
There is no need for an additional cell culture incubator, saving valuable lab space and money. Maestro Z’s smart environmental chamber finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.
>> Start your assay with the push of a button
“One button setup,” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
>> Review your results faster
The Impedance module with AxIS Z™ software provides a simplified approach to the setup, execution, and analysis of experiments.
>> Achieve 21 CFR Part 11 compliance in GLP/GMP labs
Designed with clinical translation and a regulatory environment in mind, the optional GxP Impedance Module makes the assay easy to validate and fully auditable while maintaining many of the streamlined and user-friendly features of AxIS Z.
>> Validate your assay for high throughput screening
A 384-well cytotoxicity assay using the Maestro ZHT was validated for high throughput screening, achieving high Z' ( Z'=0.81, n=2 ) with no edge effects.
>> Monitor your experiments from outside the lab
The Maestro Z App allows you to check in on your cells and experiment to ensure everything is running smoothly while you are away from the lab.
>> Increase throughput with multiple Maestros
Continuously monitor multiple plates automatically and simultaneously with multiple Maestro support. Save space in your lab by controlling multiple Maestro systems using a single computer.
Multiplex your assay: Maestro + Omni
>> Platform cross-compatibility lets you view live-cell imaging alongside real-time, functional data to enhance your analysis
>> Monitor electrode coverage and cell morphology to ensure consistent, quality results
>> Experience no-hassle tracking—the Axion Portal automatically links data via barcode
Overview
Maestro ZHT overview
Cell-based assays are critical to evaluate human biology in vitro. Many cell-based assays, however, are limited to a single snapshot in time. These endpoint assays can miss important events in cell proliferation, death, and signaling. Axion BioSystems’ Maestro ZHT platform offers continuous, label-free, impedance-based monitoring of your cells. Reveal the detailed kinetics of cell signaling interactions, cytotoxicity, and a host of drug responses for a better biological understanding without the time- and cost-intensive process of repeating multiple endpoint assays.
Software
The Maestro ZHT system is available with two software modules: Impedance and GxP Impedance. Select the software modules to match your assay needs:
Impedance – Track cell proliferation, morphology, and viability label-free and in real-time. Ideal for immuno-oncology, cytotoxicity, virology, cell migration, cell proliferation, GPCR assays, and many more.
GxP Impedance – Achieve FDA 21 CFR Part 11 compliance in GMP/GLP labs with this version of the Impedance Software Module.
Consumables
The Maestro ZHT system is compatible with the both 384- and 96-well impedance assay plate.
CytoView-Z™ – The Maestro impedance plate with a transparent well bottom for cell visualization and assay multiplexing. Available in a 384-well and 96-well plate formats.
Cross-compatible Platforms
The Maestro ZHT system has cross-compatibility with:
Omni™ – Complement your impedance assays with whole-plate images of your cultures. View electrode coverage and culture health over time with just a few clicks in AxIS Z. Compatible with the Omni and Omni Pro 12™ systems.
Related Applications
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