GxP Impedance Module overview

The GxP Impedance Module with AxIS Z makes impedance-based assays simple, fully auditable, and easy to validate. Take control of experimental settings, view real-time cellular profiles, extract straightforward endpoints, or perform in-depth analysis of cytolysis or barrier function with ease. The GxP Impedance Module has compliance features enabled, making assay validation simple.

Read the 21 CFR Part 11 Statement

Assay setup

• >> Built-in Maestro hardware test ensures impedance measurements are accurate in every experiment.
• >> User permissions ensure access to experiments and settings is controlled according to lab preferences.
• >> Assay setup is a breeze with automatic acquisition and pre-configured settings for analysis, while allowing regulated access to advanced settings as experimental needs require.
• >> Easily referenced color-coded plate map provides all the information about your experiment in real-time and tracks control types for analysis automation.

Real-time data tracking

• >> Continuous impedance data is displayed for each treatment group across the plate in real time. Drag the cursor to see a comparison across treatment groups at any time, along with a plate-wide impedance map which gives a broader comparison of effects across the plate.
• >> Built-in experiment and system-wide audit trails track who ran each experiment, the changes that were made, and preserve all original data. 
• >> An integrated barcode scanner ensures that all recorded data is associated with the correct plate, experiments are automatically sorted and logged, and events, such as plate docking, are auto-tracked. When a plate is inserted into the system, the experiment automatically resumes, so switching between plates and running parallel experiments is easy for even the busiest of labs.
• >> Automatic and user time-stamped notes indicate important events, such as dosing, and are readily available for advanced analyses, such as time reference normalization or correction with a single click.
• >> Monitor your active experiments from outside the lab with the new Maestro Z App. Use the app to check in on your cells and experiment to ensure everything is running smoothly while you are away.

Data analysis tools

• >> With the click of a button, plot percent cytolysis curves and see 50% killing time (KT50) values.
• >> Easily investigate cellular barrier integrity with AxIS Z’s Barrier Index.
• >> Generate publication-ready figures with AxIS Z’s interactive report, called the Lab Notebook, which allows you to export figures and data tables directly to Microsoft Excel®. The Lab Notebook contains fully customizable figures with live data references and error bars.
• >> Export files with checksums to ensure data integrity. Whether exporting an entire experiment or a csv file for LIMS import, easily verify that experiment data has not been changed with a single click.