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  4. Human iPSC-derived neurons reveal NMDAR-independent dysfunction following HIV-associated insults

Human iPSC-derived neurons reveal NMDAR-independent dysfunction following HIV-associated insults

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Authors: Alexander Starr, Emily Nickoloff-Bybel, Razan Abedalthaqafi, Naela Albloushi, and Kelly L. Jordan-Sciutto

Frontiers in Molecular Neuroscience, 28 January 2024

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Combining NGN2 programming with developmental patterning generates human excitatory neurons with NMDAR-mediated synaptic transmission
Verification of the seizure liability of compounds based on their in vitro functional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivo extrapolation to cerebrospinal fluid concentration
Characterization of an in vitro synaptic propagation assay using iPSC-derived neurons and multiwell MEA technology

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At Axion BioSystems, our goal is to help you capture the complex biology of your cells. Whether monitoring the kinetics of cellular growth and death or recording the activity of excitable cells; Axion BioSystems' live-cell assay technology can help you record it noninvasively, in real time, and with software tools to make analysis quick and painless.

 

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  • Products
    • MEA
      • Maestro Pro
      • Maestro Edge
      • Maestro Volt
      • MEA Software
        • Neural Module
        • MEA Viability Module
        • Cardiac Module
        • MEA Automation Module
        • GxP Impedance Module
        • Impedance Automation Module
        • Impedance Module
      • Lumos
      • MEA Creator Kit
      • BioCircuit MEA Plate
      • CytoView MEA Plate
      • Lumos MEA Plate
      • SpheroGuide MEA Plate
      • Connected Lab
    • Cell Analysis
      • Maestro Z
      • Maestro ZHT
      • Maestro TrayZ
      • Cell Analysis Software
        • Impedance Module
        • GxP Impedance Module
        • Impedance Automation Module
      • CytoView-Z Plate
    • Imaging
      • Omni Pro 12
      • Omni
      • Lux
      • Imaging Software
        • Clonogenic Assay Module
        • Confluency Module
        • Fluorescence Module
        • iPSC Module
        • Organoid Analysis Module
        • Scratch Assay Module
      • Connected Lab
    • Cell Counting
      • Corning Cell Counter
      • Exact FL
      • Cell Counting Software
        • Cell Counting Module
        • Organoid Counting Module
  • Applications
    • Cardiac Activity
      • Cardiac Characterization
      • Cardiac Classification
      • Cardiac Development
      • Cardiomyocyte Pacing
      • Cardiotoxicity and Safety
      • Inotropy
    • Cell-based Assays
      • Barrier Function
      • Cell Counting
      • Cell Migration and Scratch Assays
      • Cell Proliferation
      • Cell Signaling
      • Clonogenic Assay
      • Cytotoxicity and Cell Viability
      • Transfection and Transduction
      • Organ-on-a-chip
    • Neural Activity
      • Neural Characterization and Development
      • Neural Circuit and Innervation
      • Neural Co-culture and Glial Interaction
      • Neural Optical and Electrical Stimulation
      • Neural Organoids
      • Neurological Disease
        • Alzheimer's Disease
        • Amyotrophic Lateral Sclerosis (ALS)
        • Autism
        • Epilepsy
        • Glioma
        • Parkinson's Disease
      • Neuromuscular Junction
      • Neurotoxicology and Safety
      • Pain
      • Retina
      • Zebrafish
    • Oncology
      • Cancer Spheroid
      • Cell Proliferation
      • Clonogenic Assay
      • Cytotoxicity and Cell Viability
      • Glioma
      • Immuno-oncology Assays
        • Antibody-dependent cellular cytotoxicity (ADCC)
        • CAR T Cell Killing
        • Cell Migration and Scratch Assays
        • NK Cell Killing
      • Liquid Tumors
    • Stem Cell Culture
      • Cardiac Development
      • iPSC Organoid Models​
      • Neural Characterization and Development
      • Neural Organoids
      • Organ-on-a-chip
      • Stem Cell Monitoring
    • Virology
      • Antiviral Drug Studies
      • Viral Titer
  • Resources
    • Axion iPSC Model Standards (AIMS)
    • Cell Plating Calculator
    • Resources
    • Resources for Publishing Your Research
    • Customer Stories
  • About Us
    • Locations
    • Join Our Team
    • Leadership Team
    • Neuroscience Scientific Advisory Board
    • Our History
    • Technology
    • Travel Awards
    • Events
    • Axion World Tour
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    • Scientific Web Tools
  • Contact Us
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